The war on bio-terrorism continues as Chris Redfield, Leon Kennedy, and other famous Resident Evil stalwarts battle a seemingly familiar adversary. However, as these veterans of survival horror pursue this latest threat, their nightmare reaches critical mass when it is discovered that it is in fact Ada Wong's dark clone, Carla, who is championing the most deadly bio-weapon yet - the C-Virus. Chris and Leon have eradicated some of the worst viral strains, from Raccoon City and beyond. But can they overcome this most deadly strain yet? Moreover, when push comes to shove, can they shed old compassion and take down their former friends? How will a conflicted young Wesker come to terms with his lineage, and where will his true alliance fall in this deadly chess match?