fakekillermac20718

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why does smokin weed give us the munchies???

0 views    posted 18 Jul 2012, 01:32    
-Marijuana--or more specifically its active ingredient, tetrahydrocannabinol--has a well-documented tendency to stimulate hunger. And while scientists have traced this property to cannabinoid receptors in the brain, they have had little understanding of the neural circuitry underlying this effect.
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Understanding this circuitry has important practical implications because blocking the cannabinoid receptor, CB1, offers a promising approach to treating obesity. One such compound, rimonabant (trade name AcompliaTM) is already undergoing clinical testing.

In an article in the December 22, 2005, issue of Neuron, Young-Hwan Jo and colleagues report how the circuitry of CB1 is integrated with signaling by the appetite-suppressing hormone leptin. The CB1 receptor is normally triggered by natural regulatory molecules, called endocannabinoids.

In their studies, the researchers concentrated on the lateral hypothalamus (LH) of the brain, known to be a center of control of food intake. Their studies involved detailed electrophysiological measurements of the effects of specific neurons that they had identified in previous studies as being important in endocannabinoid signaling.

Their studies revealed that activation of CB1 receptors, as by endocannabinoid molecules, induced these neurons to be rendered more excitable by a mechanism called "depolarization-induced suppression of inhibition" (DSI).

What's more, they found that leptin inhibits DSI. However, they found that leptin did not interfere with the CB1 receptors themselves. Rather, leptin "short-circuits" the endocannabinoid effects by inhibiting pore-like channels in the neurons that regulate the flow of calcium into the neurons. Such calcium is necessary for the synthesis of endocannabinoids.

In further studies of mice genetically altered to be leptin deficient, the researchers found the DSI to be more prolonged than in normal mice. Thus, they said, the findings "implicate this mechanism for leptin receptor/endocannabinoid signaling in contributing to the maintenance of weight balance…." The researchers also included that "upregulation of endocannabinoid signaling in the LH may explain, at least in part, the increased body weight consistent with a prior report of elevated endocannabinoids" in such leptin-deficient mice.

The researchers concluded that their findings "are consistent with the hypothesis that the integration of endocannabinoid and leptin signaling regulates the excitability of neurons on appetite-related circuits."

They also wrote that "the cellular mechanisms of recently developed antiobesity drugs, such as rimonabant, may include decreased endocannabinoid signaling and hence decreased excitability of LH circuits related to appetite, even in the context of leptin insufficiency or resistance."

I dont expect everyone to understand all the technical talk in this blog just know that cannabis affects ur brain in such a way as to make u hungry lol

Top Comments

3
Flash4505279 • 18 Jul 2012, 02:56
Having A little Experience in this area (35 Years), and Being A legal card-carrying member due to medical reasons now, I find it ludicrous that this miracle plant,is not being put to better use huffy. Not only are it's medical effects beneficial(Used properly and has been used for over 5,000 years), not just to get high, Its Industrial uses (Some 30,000)-yes THIRTY THOUSAND! are proven facts and it's nutritional value is second only to soybeans( Who would rather eat pot than tofuwink)Is an excellent source of omega-3 Fatty acids, 21% Fat,22% Protein, 15% RDA of IRON, 25% Zinc, 50% Phosphorous and Magnesium, I could go on and on- Should Write my own Blogtongue. Thanks for fakekillermac420 for Bringing the topic up..biggrin. And as for the Effects on the body, it not only heightens your taste bud senses, it can effect all your senses and allows people to become more creative in Art, Music, Literature and even helps in psychotherapy when used properly..

All Comments

0
EDAW106594 • 19 July 2012, 00:10 Show comment
More education what a bargain...Well its LEGAL here in Calif. I live in Los Angeles...and even though its LEGAL we still got the LAPD and DEA kickin down Dispensary doors. Our City Gov't is so shady with corruption that cities like San Bernadino and Compton are claiming bankruptcyshocked. I carry a card and know that all our financial woes can be over as soon as they get with the dispensaries and tax them and leave them the hell alone after that. Anybody buying from the store would benefit the community and the city..thnx again for the education ...peace EDAW
0
Hayeda255 • 18 July 2012, 17:43 Show comment
All this crap about saving the world, and mother earth has provided us with this majestic plant, and the government is burning it down...
0
TimeBandits74.38K • 18 July 2012, 21:38 Show comment
and inhaling the smoke, dam them!!titter

1
dd537873176 • 18 July 2012, 14:09 Show comment
I agree that it gives one the munchies, I don't smoke any longer but I did quite a bit when I was a young pup, I also agree it should be legalized, stupid govt wants to make money off us. But one thing I did notice over the years that it does inhibit the brain activity, as in There's a reason that Harold and Kumar etc. do stupid things. When I quit I noticed my mental faculties slowly ascended as well. If you look at stargazers post he alludes to the same realization.
0
Stargazer10162.99K • 18 July 2012, 13:53 Show comment
I use to smoke nearly a quater a day of hydro and to tell the truth,when you have a habit like that it has the opposite affect on your eating habbits.After quitting about 6 months ago after many years my weight increased 15kg and the brain started to work properly again but sometimes my short term memory isnt the best still but im fairly sharp again.Yes pot has good uses but like anything if you abuse it there can be consequences.Clean again and ill never go back.Its suppose to be a social thing not an all day thingwink
1
dd537873176 • 18 July 2012, 14:13 Show comment
Amazed that someone else noticed the same thing, when I quit several times I noticed a change in my mental well being. Thanks for the post Stargazer101. I like it but I want my mentality to be 100%, so I am staying off it.
1
TimeBandits74.38K • 18 July 2012, 21:40 Show comment
It's never gonna be 100%.titter

0
pnfuploads1848 • 18 July 2012, 05:49 Show comment
I dont really understand. I'll just go to white castle around midnight and I'll ask someone there. titter
3
Flash4505279 • 18 July 2012, 02:56 Show comment
Having A little Experience in this area (35 Years), and Being A legal card-carrying member due to medical reasons now, I find it ludicrous that this miracle plant,is not being put to better use huffy. Not only are it's medical effects beneficial(Used properly and has been used for over 5,000 years), not just to get high, Its Industrial uses (Some 30,000)-yes THIRTY THOUSAND! are proven facts and it's nutritional value is second only to soybeans( Who would rather eat pot than tofuwink)Is an excellent source of omega-3 Fatty acids, 21% Fat,22% Protein, 15% RDA of IRON, 25% Zinc, 50% Phosphorous and Magnesium, I could go on and on- Should Write my own Blogtongue. Thanks for fakekillermac420 for Bringing the topic up..biggrin. And as for the Effects on the body, it not only heightens your taste bud senses, it can effect all your senses and allows people to become more creative in Art, Music, Literature and even helps in psychotherapy when used properly..
1
420weedman45.22K • 18 July 2012, 03:24 Show comment
i strongly agree with you and fakekillermac420

1
JfiSG1nG3496 • 18 July 2012, 02:51 Show comment
wrong user link it sounds like you may indulge in the sweet green from time to time. Just guessing, with the regularity you blog about it and all titter
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